Sirius Therapeutics is a global clinical-stage biotechnology company dedicated to unlocking the clinical and commercial value of siRNA therapeutics. The Company’s goal is to transform the current standard of care for chronic diseases by developing first-in-class and best-in-class siRNA therapeutics for large unmet global medical needs, a strategy underpinned by three mega-blockbuster franchises, proprietary siRNA technology platform (PEPR) and global partnership and capabilities.

Sirius is focused on three mega-blockbuster franchises, targeting coagulation disorders, cardiometabolic diseases, and obesity.

Sirius Therapeutics was founded in 2021 and is a globally integrated biotechnology company with dual headquarters in San Diego, USA, and Shanghai, China. The Company’s strategic advantage is rooted in a hybrid operational model that seamlessly combines the exceptional early development capacity and cost-efficiency of the Company’s China-based team with the global discovery and regulatory expertise of the U.S.-based team.

Key Milestones

2025

  • September

    First patient dosed in SRSD107 Phase 2 trial in Europe

  • July

    EMA approval for SRSD107 Phase 2 trial in Europe

  • April

    Multi-target collaboration agreement signed with CRISPR Therapeutics

  • Series B2 financing: nearly US$50mn raised

  • FDA clearance of IND for SRSD216 to begin clinical trials in USA May

  • March

    NMPA approval for SRSD216 Phase 1/2a trial in China

2024

  • December

    Announced data from SRSD107 Phase 1 trial in Australia

  • April

    First patient in dosed in SRSD107 Phase 1 trial in China

  • March

    NMPA approval for SRSD107 Phase 1 trial in China

  • Received IND clearance of SRSD107 by NMPA

  • February

    First patient dosed in SRSD107 Phase 1 trial in Australia

  • Completed the FIH of SRSD107 in Australia

2023

  • December

    Established US site in San Diego

  • November

    Received IND clearance of SRSD101 by NMPA

  • Submitted the HRECs in Australia of SRSD107

  • September

    Completed Series B financing

  • August

    Submitted the first IND to China NMPA

2022

  • November

    Established company’s new office in Shanghai,China

  • July

    Completed Series A financing

  • March

    Sirius China was officially established

2021

  • December

    Established US Office in Boston

  • June

    Sirius US was officially established

2025

2024

2023

2022

2021

Sirius Therapeutics, Inc., all rights reserved

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